Psychedelic drug development beyond mental health.
TRYP THERAPEUTICS CSE:TRYP | OTC:TRYPF
Psychedelic stock Tryp Therapeutics is pursuing vast market potential by targeting chronic pain and other indications rather than mental health.
Indeed, the pioneering psychedelic company is developing treatments for some of the world’s most crippling pain and eating disorders. These include fibromyalgia, phantom limb pain, binge eating disorder and hypothalamic obesity and complex regional pain syndrome (CRPS).
Realizing the full potential of psychedelics
It may be surprising to learn that debilitating pain can be treated with psychedelics. The reason being, many types of chronic pain originate in the brain, so psychedelics can potentially help rewire the brain to address the source of the pain rather than just treating the symptoms.
Tryp Therapeutics is on a mission to develop psilocybin-based treatments for chronic pain and eating disorders. These conditions are all too common, and those suffering are desperately underserved.
Can Tryp Therapeutics help alleviate fibromyalgia?
Fibromyalgia is a painful and draining illness. It’s believed to affect as many as 1 in 20 people globally, and more than 4 million people in the U.S. have been diagnosed with the disease. That’s an enormous addressable market desperately seeking pain relief.
Nearly 30% of fibromyalgia patients are currently prescribed opioids to manage their pain.
Apart from the risk of overdose and addiction, prolonged use can cultivate a self-destructive spiral that ruins multiple lives.
Therefore, anything that can ease pain and reduce suffering is greatly sought after.
And this is where psilocybin stands to shine.
Recreating neural connections and identifying pain triggers can be transformative in managing the root of the pain and other symptoms of fibromyalgia. And psilocybin has outstanding potential to do just that.
But it’s not just fibromyalgia sufferers that stand to benefit.
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Switching off the phantom limb pain trigger
Despite their heroic efforts, many US military veterans return battle-scarred and limbless, only to suffer such horrors as PTSD and phantom limb pain.
Of course, it’s not just veterans suffering. Phantom limb pain affects over a million people in the US.
This is a shocking number to be left in limbo. Indeed, over 60% of patients who have lost a limb suffer from this distressing condition.
While other psychedelic research studies are already addressing PTSD, Tryp Therapeutics focuses on how psilocybin can relieve phantom limb pain.
By pioneering patented formulations for synthetic psilocybin, it hopes to tackle this horrifying problem head-on.
But that’s not all.
Eating disorders lead to depression
As the world has become increasingly body-conscious, eating disorders are on the rise. Another alarming statistic shows close to 3.5% of females and 2% of males suffer from a binge eating disorder throughout their lives.
The world’s obesity problem is getting worse, and weight loss solutions are more prevalent than ever. But few actually work, and this cyclical process of binge eating puts terrible pressure on the body and mind.
Tryp Therapeutics hopes to solve the decades-old problem of binge eating while patenting its targeted formulations and pioneering new ways to manufacture the drugs along the way.
As well as binge eating, Tryp Therapeutics is focusing on a much rarer eating disorder known as hypothalamic obesity. There are less than 10k diagnosed cases in the US, but these individuals are left to suffer in silence with no approved treatments.
Combatting the ‘suicide disease’
Finally, Tryp Therapeutics is also targeting complex regional pain syndrome (CRPS).
Little known but excruciatingly painful, CRPS affects nearly 100k individuals in the US. Indeed, CRPS can be one of the most painful of all medical disorders.
Devastatingly nicknamed the ‘suicide disease,’ CRPS desperately needs better treatment options.
CRPS is caused by persistent pain that the brain has learned from a prior injury that has already fully healed. The brain gets stuck in a pain loop that can seem to have no end.
Psychedelic therapies can alter the mind and the connections within the brain, potentially offering CRPS sufferers a chance at pain relief.
It is utterly cruel to let people suffer in such unbearable pain that suicide can seem for many to be their only way out. Surely an opportunity to alleviate such pain should be explored?
Tryp Therapeutics thinks so, and that’s why it’s targeting the disease while pursuing global patents at every opportunity.
The power of psychedelics beyond mental health is largely untapped, and a broader universe of use cases are opening up. That’s why Tryp Therapeutics is tapping into this underexplored area of chronic pain and other diseases.
Tryp Therapeutics is playing in the big leagues
TRYP THERAPEUTICS CSE:TRYP | OTC:TRYPF
Tryp Therapeutics has already filed a provisional patent application and has several more in the pipeline.
This is tremendously impressive because, despite its size, it’s playing in the big leagues with peers such as Compass Pathways and MindMed.
Only a handful of highly-regarded players in the psychedelics field have already kicked-off their Phase 2 clinical trials. Compass Pathways is finalizing a Phase 2b study for treatment-resistant depression. While non-profit organization MAPS has completed a Phase 3 study for PTSD.
Their success paves the way for others in the space. This is where Tryp Therapeutics shows a distinct advantage because it can go straight to Phase 2 thanks to the extensive amount of safety data already produced on psilocybin.
Furthermore, the risk of failure decreases, and value increases with each major milestone achieved along the clinical path.
And as Tryp Therapeutics leads the next generation of clinical research into psychedelic drug development focused on pain relief, it presents a significant upside opportunity for shareholders.
There are three significant milestones in clinical development, and each phase takes considerable time and effort:
Submitting an Investigational New Drug (IND) application to the FDA
Enrolling the first patient in the trial
Tryp Therapeutics already has one IND submission under its belt, with another right around the corner. This is a process that requires hundreds of collaborative, scientific effort and is a significant milestone to pass.
The recent filing of an IND for its upcoming Phase 2a study with the University of Florida is among several academic collaborations that Tryp Therapeutics will be announcing soon. Tryp Therapeutics will also be submitting an IND for its Phase 2a clinical trial for fibromyalgia with the University of Michigan in 4Q 2021.
Meanwhile, for its first Phase 2a trial, Tryp Therapeutics has partnered with Jennifer Miller, M.D., an expert in eating disorders. The company expects to enroll its first patients in the study before the end of the year.
Tryp Therapeutics is progressing with two formulations. One is a standard oral form of synthetic psilocybin, while the other is a psilocybin-based product that offers an improved way to administer the drug. The goal is to improve the patient experience
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Impressive scientific support
Robin Carhart-Harris, Ph.D. is Chairman of Tryp Therapeutics’ Scientific Advisory Board. This is an extremely impressive individual to back the team.
Carhart-Harris is a psychologist, neuroscientist, and pioneer of psychedelic therapies. In fact, he has published more papers on psilocybin than anyone else in the world.
He trained under the mentorship of Professor David Nutt and recently featured in a BBC documentary called The Psychedelic Drug Trial. Furthermore, he’s Head of the Centre for Psychedelic Research, Division of Brain Sciences at Imperial College London, and Director of the Neuroscape Psychedelic Division at the University of California, San Francisco.
Earlier this year, Dr. Robin Carhart-Harris said:
“I’M DELIGHTED TO BE JOINING THE TRYP THERAPEUTICS TEAM. AMIDST THE RAPID GROWTH OCCURRING IN THE PSYCHEDELIC PHARMACEUTICAL SPACE, TRYP THERAPEUTICS STANDS OUT AS ONE OF THE MOST WELL OPERATED COMPANIES I HAVE COME ACROSS. I’M IMPRESSED BY THE BREADTH AND DEPTH OF THEIR EXPERIENCE IN DRUG DEVELOPMENT AND AM PLEASED TO BE COMPLEMENTING THIS TEAM WITH MY OWN PSYCHEDELIC-SPECIFIC EXPERTISE.”
Several impressive figures accompany Carhart-Harris on the Scientific Advisory Board.
Daniel Clauw, M.D. is Scientific Advisor to Tryp Therapeutics. He’s a world-leading expert in fibromyalgia and other nociplastic pain indications. Dr. Clauw is also Director of the Chronic Pain & Fatigue Research Center and Professor of Anesthesiology, Medicine, and Psychiatry at the University of Michigan Medical School.
Psychedelic stocks are hot right now!
Psychedelic drug development remains among the hottest sectors of the biotech industry.
There are several reasons to be excited about investing in Tryp Therapeutics Therapeutics. It’s one of very few psychedelic drug development companies that have submitted IND’s for Phase 2 clinical trials.
Moreover, with two of these starting soon and another two early next year, it will be as advanced in the clinic as its much larger peers.
This represents a significant upside opportunity to Tryp Therapeutics’ share price. Plus, a unique and undervalued prospect for investors.
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