As Myocarditis Debate Rages On, Heart Disease Cases Mount

By Kirsteen Mackay

Share:

In this article

  • Loading...
  • Want to see what you should be buying? Check out our top picks.

Few had heard of myocarditis before the pandemic, but now it’s a serious worry making global headlines. One company is hoping to treat it.

As COVID-19 vaccines for kids achieve the Centers for Disease Control and Prevention (CDC) recommendation, concern it could increase children’s chances of myocarditis has incurred deep debate. Myocarditis is a rare heart disease that causes inflammation of the heart muscle. Some companies tackling the world’s biggest health threats, such as heart disease, include Johnson & Johnson (NYSE: JNJ), Takeda Pharmaceutical Co Ltd (NYSE: TAK), Novo Nordisk A/S (NYSE: NVO), Bristol-Myers Squibb Co (NYSE: BMY), and Cardiol Therapeutics (NASDAQ: CRDL) (TSX: CRDL).

Myocarditis Concern

Moderna previously confirmed the FDA delayed approval of its child vaccination due to the risk of myocarditis. The concern came after instances of myocarditis transpiring in young men after their second dose of an mRNA vaccine. Acute myocarditis is a significant cause of acute and fulminant heart failure in young adults and a leading cause of sudden cardiac death in people under 35 years old. This is raising alarm and driving interest in workable treatments.

Before the pandemic, few had heard of myocarditis, but now it’s a serious worry and parents everywhere are discussing it.

For now, the risk of myocarditis appears to be deemed small, although the debate has drawn awareness of this inflammatory condition to the public domain.

Nevertheless, in some cases, myocarditis can lead to heart failure, so parental concern is warranted.

With myocarditis cases rising, it could further exacerbate the global heart failure problem. It’s not only devastating lives but adds pressure to healthcare providers and is a growing economic burden. According to the CDC, cardiovascular diseases (CVD) are the biggest cause of death, with more than 800,000 Americans suffering from heart attacks yearly. Sadly, this problem is mounting and is further exacerbated by obesity, diabetes, hypertension, and now COVID-19.

At a time when heart disease cases and other global health concerns are mounting, the desire for suitable treatments has never been greater.

At Novo Nordisk, cardiovascular researchers focus primarily on identifying new ways to treat cardiovascular diseases, particularly atherosclerosis and chronic heart failure. It is also developing life-altering diabetes and weight loss drugs. And Johnson & Johnson is working on treatments for respiratory diseases, which are often linked to heart disease.

Meanwhile, Takeda’s Flexbumin drug is an albumin solution indicated for use in cardiopulmonary bypass surgery. Bristol-Myers Squibb is advancing its research in cardiovascular diseases, and thankfully, Cardiol Therapeutics (NASDAQ: CRDL) (TSX: CRDL) is doing something about myocarditis. This clinical-stage company is focused on researching and developing an anti-inflammatory and anti-fibrotic therapy for the treatment of CVD. Cardiol’s primary focus is on treating inflammatory heart conditions, particularly acute myocarditis, recurrent pericarditis, and diastolic heart failure.

Making Cardiovascular Strides With CardiolRx™

The company’s lead product candidate, CardiolRx™, is a pharmaceutically produced oral cannabidiol formulation being clinically developed for use in cardiovascular medicine. The pre-clinical data for this is compelling, as it displays potent anti-inflammatory and anti-fibrotic properties. It's this data that has led so many esteemed individuals to back these trials and invest themselves in Cardiol’s journey.

Altogether there’s great excitement for the efficacy of CardiolRx™ in multiple use cases and, therefore, the potential for the company to profit from several revenue streams in the future. If its drug proves to be that elusive treatment, it will surely be a cause for celebration.

Cardiol currently has one multi-national clinical trial ongoing and has received IND authorization from the FDA to conduct clinical studies to evaluate the efficacy and safety of CardiolRx™ in two orphan disease indications: acute myocarditis and recurrent pericarditis. Cardiol’s Phase 2 multi-national, randomized, double-blind, placebo-controlled trial in acute myocarditis is expected to begin imminently. To run in parallel with the Company’s acute myocarditis trial is a multi-center Phase 2 open-label pilot study of CardiolRx™ for recurrent pericarditis.

With the world facing intensifying healthcare challenges, doctors welcome potential breakthroughs in treating rare diseases.

Johnson & Johnson (NYSE: JNJ) subsidiary Janssen Pharmaceutica is running the Heartline study with Apple to study atrial fibrillation and how wearable technologies can help people identify atrial fibrillation to reduce the likelihood of an adverse health outcome.

Takeda Pharmaceutical Co Ltd (NYSE: TAK) is a leader in bleeding disorders. The company recently signed a 15-year lease with BioMed Realty for building approximately 600,000 square feet of research and development (R&D) and office space. The state-of-the-art facility will allow Takeda, the largest life sciences employer in Massachusetts, to create a purpose-built R&D facility with laboratories of the future featuring modern design elements and upgraded technology to support the company in its efforts to advance innovation for patients. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). The company also makes targeted R&D investments in Plasma-Derived Therapies and Vaccines.

Novo Nordisk A/S (NYSE: NVO) has partnered with Echosens, a high-technology company offering liver diagnostic solutions. Together they hope to advance the early diagnosis of non-alcoholic steatohepatitis (NASH) and increase awareness of the disease among patients, healthcare providers and other stakeholders.

Bristol-Myers Squibb Co (NYSE: BMY) is evaluating multiple novel agents to address the needs of patients with serious cardiovascular conditions. The company has established the Bristol Myers Squibb Foundation to focus on providing social support and services for vulnerable and under-resourced populations to both educate and reduce the cost of cardiovascular care.

Along with heart disease, additional global health concerns include gastrointestinal diseases, cancer, and diabetes. All of which poses a growing burden to health care systems and humanity alike.

Abbott Laboratories (NYSE: ABT) is tackling the growing threat of diabetes. It recently announced late-breaking clinical data that demonstrates its FreeStyle Libre® 3 system has an overall mean absolute relative difference (MARD) of 7.9%,1 making it the first and only 14-day continuous glucose monitoring (CGM) system to achieve a sub-8% overall MARD. The results were presented at the American Diabetes Association® (ADA) 82nd Scientific Sessions, June 3-7, 2022, in New Orleans.

Merck (NYSE: MRK) recently announced a collaboration with Finnish pharmaceutical company Orion. Merck hopes to develop and commercialize Orion’s ODM-208, an Investigational Steroid Synthesis Inhibitor for the treatment of metastatic castration-resistant prostate cancer. Merck will make an upfront payment to Orion of $290m, which will be expensed by Merck in Q3, 2022 and included in non-GAAP results. Merck is known as MSD outside of the United States and Canada. It is also studying its drug KEYTRUDA in early-stage cancers, with approximately 20 ongoing registrational studies across multiple types of cancer.

Novartis AG (NYSE: NVS) is a focused medicines company with depth in five core therapeutic areas (hematology, solid tumors, immunology, neuroscience and cardiovascular), strength in technology platforms (gene therapy, cell therapy, radioligand therapy, targeted protein degradation and xRNA), and a balanced geographic footprint. The company's key growth brands include Cosentyx, Entresto, Kesimpta, Zolgensma, Kisqali and Leqvio. Its six key in-market growth drivers with multi-billion sales potential (Cosentyx, Entresto, Zolgensma, Kisqali, Kesimpta, Leqvio) each grew at least double digits during Q2, 2022.

ACADIA Pharmaceuticals Inc. (NASDAQ: ACAD) is advancing breakthroughs in neuroscience to elevate life. Therapeutic areas it is investigating include acute and chronic pain and breakthrough treatment for Alzheimer’s disease psychosis. ACADIA is also trialing therapeutics to alleviate symptoms in the rare genetic neurodevelopment disorder Rett syndrome. The company submitted a New Drug Application (NDA) to the US FDA in July. This NDA is for trofinetide for the treatment of Rett syndrome in adults and pediatric patients two years of age and older. Rett syndrome is a devastating disease with no approved therapies. The NDA submission is supported by results from the pivotal Phase 3 Lavender™ study evaluating the efficacy and safety of trofinetide versus placebo in 187 girls and young women aged 5-20 years with Rett syndrome.

Medtronic PLC (NYSE: MDT) is an American medical device company and global leader in healthcare technology. In mid-July 2022, the American Society for Gastrointestinal Endoscopy (ASGE) announced they are expanding the Medtronic Health Equity Assistance Program for colon cancer screening in medically underserved communities across the United States, with support from Amazon (NASDAQ: AMZN) Web Services (AWS) Health Equity Initiative. The GI Genius units provided as part of the program have increased from 50 to 133 systems being placed at 62 facilities.

Share:

In this article:

Topics:
Healthcare Services
Healthcare Technology
Industries:
Healthcare
Companies:
Cardiol Therapeutics
Novo Nordisk A/S
Johnson & Johnson
Takeda Pharmaceutical

IMPORTANT NOTICE AND DISCLAIMER

PAID ADVERTISEMENT

This communication is a paid advertisement. ValueTheMarkets is a trading name of Digitonic Ltd, and its owners, directors, officers, employees, affiliates, agents and assigns (collectively the “Publisher”) is often paid by one or more of the profiled companies or a third party to disseminate these types of communications. In this case, the Publisher has been compensated by Cardiol Therapeutics to conduct investor awareness advertising and marketing and has paid the Publisher the equivalent of One Hundred and Eighty Thousand Dollars to produce and disseminate this and other similar articles and certain related banner advertisements. This compensation should be viewed as a major conflict with the Publisher’s ability to provide unbiased information or opinion.

CHANGES IN SHARE TRADING AND PRICE

Readers should beware that third parties, profiled companies, and/or their affiliates may liquidate shares of the profiled companies at any time, including at or near the time you receive this communication, which has the potential to adversely affect share prices. Frequently companies profiled in our articles experience a large increase in share trading volume and share price during the course of investor awareness marketing, which often ends as soon as the investor awareness marketing ceases. The investor awareness marketing may be as brief as one day, after which a large decrease in share trading volume and share price may likely occur.

NO OFFER TO SELL OR BUY SECURITIES

This communication is not, and should not be construed to be, an offer to sell or a solicitation of an offer to buy any security.

INFORMATION

Neither this communication nor the Publisher purport to provide a complete analysis of any company or its financial position.

This communication is based on information generally available to the public and on an interview conducted with the company’s CEO, and does not contain any material, non-public information. The information on which it is based is believed to be reliable. Nevertheless, the Publisher does not guarantee the accuracy or completeness of the information. Further, the information in this communication is not updated after publication and may become inaccurate or outdated. No reliance should be placed on the price or statistics information and no responsibility or liability is accepted for any error or inaccuracy. Any statements made should not be taken as an endorsement of analyst views.

NO FINANCIAL ADVICE

The Publisher is not, and does not purport to be, a broker-dealer or registered investment adviser or a financial adviser. The Publisher has no access to non-public information about publicly traded companies. The information provided is general and impersonal, and is not tailored to any particular individual’s financial situation or investment objective(s) and this communication is not, and should not be construed to be, personalized investment advice directed to or appropriate for any particular investor or a personal recommendation to deal or invest in any particular company or product. Any investment should be made only after consulting a professional investment advisor and only after reviewing the financial statements and other pertinent corporate information about the company. Further, readers are advised to read and carefully consider the Risk Factors identified and discussed in the advertised company’s SEC, SEDAR and/or other government filings. Investing in securities, particularly microcap securities, is speculative and carries a high degree of risk. Past performance does not guarantee future results.

FORWARD LOOKING STATEMENTS

This communication contains forward-looking statements, including statements regarding expected continual growth of the featured companies and/or industry. Statements in this communication that look forward in time, which include everything other than historical information, are based on assumptions and estimates by our content providers and involve risks and uncertainties that may affect the profiled company’s actual results of operations. These statements involve known and unknown risks, uncertainties and other important factors that could cause the actual results and performance to differ materially from any future results or performance expressed or implied in the forward-looking statements. These risks, uncertainties and other factors include, among others: the success of the profiled company’s operations; the size and growth of the market for the company’s products and services; the company’s ability to fund its capital requirements in the near term and long term; pricing pressures; changes in business strategy, practices or customer relationships; general worldwide economic and business conditions; currency exchange and interest rate fluctuations; government, statutory, regulatory or administrative initiatives affecting the company’s business.

INDEMNIFICATION/RELEASE OF LIABILITY

By reading this communication, you acknowledge that you have read and understand this disclaimer in full, and agree and accept that the Publisher provides no warranty in respect of the communication or the profiled company and accepts no liability whatsoever. You acknowledge and accept this disclaimer and that, to the greatest extent permitted under applicable law, you release and hold harmless the Publisher from any and all liability, damages, injury and adverse consequences arising from your use of this communication. You further agree that you are solely responsible for any financial outcome related to or arising from your investment decisions.

TERMS OF USE AND DISCLAIMER

By reading this communication you agree that you have reviewed and fully agree to the Terms of Use found here https://www.valuethemarkets.com/terms-conditions/ and acknowledge that you have reviewed the Disclaimer found here https://www.valuethemarkets.com/disclaimer/. If you do not agree to the Terms of Use, please contact valuethemarkets.com to discontinue receiving future communications.

INTELLECTUAL PROPERTY

All trademarks used in this communication are the property of their respective trademark holders. Other than valuethemarkets.com, the Publisher is not affiliated, connected, or associated with, and the communication is not sponsored, approved, or originated by, the trademark holders unless otherwise stated. No claim is made by the Publisher to any rights in any third-party trademarks other than valuethemarkets.com.

AUTHORS: VALUETHEMARKETS

valuethemarkets.com and Digitonic Ltd and our affiliates are not responsible for the content or accuracy of this article. The information included in this article is based solely on information provided by the company or companies mentioned above. This article does not provide any financial advice and is not a recommendation to deal in any securities or product. News and research are not recommendations to deal, and investments may fall in value so that you could lose some or all of your investment. Past performance is not an indicator of future performance.

ValueTheMarkets do not hold any position in the stock(s) and/or financial instrument(s) mentioned in the above piece. ValueTheMarkets have been paid to produce this piece by the company or companies mentioned above. Digitonic Ltd, the owner of valuethemarkets.com, has been paid for the production of this piece by the company or companies mentioned above.


Sign up for VTM Updates

Form submitted successfully!

VTM Exclusive Reports

Crypto Corner

Learn your NFTs from your BTCs