Patients Welcome Relief from Particle Pollution Harm

By Patricia Miller

Share:

In this article

  • Loading...
  • Want to see what you should be buying? Check out our top picks.

Poor air quality, in part caused by issues surrounding climate change, has forced these healthcare companies into looking at ways to combat heart and lung disease problems around the world.

Particulate matter or particle pollution is a significant contributor to heart and lung disease. Individuals most affected by poor air quality have asthma, chronic obstructive pulmonary disease (COPD), and heart disease. Some of the companies tackling these soaring health problems include GlaxoSmithKline (NYSE: GSK), AstraZeneca (NASDAQ: AZN), Regeneron Pharmaceuticals Inc (NASDAQ: REGN), and Cardiol Therapeutics (NASDAQ: CRDL) (TSX: CRDL).

Particulate matter pollution is prevalent because their minuscule size means people often inhale these particles effortlessly. They then infiltrate blood vessels, damaging the heart and lungs. Familiar sources include automobile and diesel generator emissions, wood and tobacco smoke, wildfires and even fireworks.

Despite extensive efforts to combat climate change, it seems the world has a long way to go to achieve clean air all around. This means any help to alleviate the associated health concerns is warmly welcomed.

Last year GSK began an R&D program to redevelop and redesign its rescue metered-dose inhalers (MDIs) to lower its carbon emissions while continuing to provide relief to asthmatics.

A recent asthma study published in the British Medical Journal (BMJ) showed that patients switching from a pressurized metered-dose inhaler (pMDI) to a dry powder inhaler (DPI)-based maintenance therapy more than halved their inhaler carbon footprint without loss of asthma control.

Regeneron Pharmaceuticals, along with The National Institute of Allergy and Infectious Diseases (NIAID) and Sanofi, are co-funding a Phase 2 clinical trial. This will test whether a monoclonal antibody, dupilumab, can reduce asthma attacks and improve lung function and asthma symptoms in children with poorly controlled allergic asthma who live in low-income urban neighborhoods.

Meanwhile, AstraZeneca is on a mission to transform the treatment of asthma and COPD by driving earlier, biology-led treatment, eliminating preventable asthma attacks, and removing COPD as a top-three leading cause of death.

However, cardiovascular diseases remain the world’s primary cause of death. Indeed, more than 800,000 Americans suffer from heart attacks annually, according to the Centers for Disease Control and Prevention (CDC). Furthermore, 2018 CDC data indicates more than 30 million Americans live with heart disease.

Inhaling microscopic pollution particles can lead to arrhythmia, inflammation and hypercoagulation.

Cardiol Therapeutics (NASDAQ: CRDL) (TSX: CRDL) is one company attempting to tackle the debilitating effects of heart conditions. The company aims to treat inflammatory heart conditions of acute myocarditis, recurrent pericarditis, along with diastolic heart failure.

Cardiol Therapeutics is developing CardiolRx™, a pharmaceutically produced oral cannabidiol formulation to potentially treat acute inflammation associated with heart disease.

Cardiol currently has one multi-national clinical trial ongoing with another expected to commence imminently. Plus, it recently announced its third FDA IND authorization for its flagship formulation CardiolRx™ in cardiovascular disease.

Altogether, the company is looking to treat three areas of concern that would greatly benefit from an alternative treatment breakthrough.

PHASE II RECURRENT PERICARDITIS TRIAL

Cardiol's latest IND authorization is for a multicenter Phase II open-label pilot study of CardiolRx™ for recurrent pericarditis. This study will run parallel to the company's multi-national Phase II acute myocarditis trial.

Cardiol's recurrent pericarditis study will also assess the improvement in objective measures of disease and, during an extension period, evaluate the feasibility of weaning concomitant background therapy, including corticosteroids, while taking CardiolRx™.

Allan L. Klein, MD, FRCP (C), FACC, FAHA, FASE, FESC, Director Center of Pericardial Diseases and Professor of Medicine, Heart and Vascular Institute, Cleveland Clinic, will serve as study Chair and provide leadership throughout the trial.

Cardiol's study is expected to enroll 25 patients at major clinical centers specializing in pericarditis in the United States. The study protocol has been designed in collaboration with well-established thought leaders in pericardial disease.

Cardiol Therapeutics’ Chief Medical Officer, Dr. Andrew Hamer, commented:

“With Investigational New Drug authorization now in place, we look forward to ramping up initiation of this important study. We also anticipate benefiting from the clinical trial infrastructure already established for our multi-national acute myocarditis study, which is expected to commence patient enrollment imminently.”

Pericarditis refers to inflammation of the pericardium – the membrane or sac surrounding the heart. Symptoms include debilitating chest pain, shortness of breath, and fatigue, which result in physical limitations, reduced quality of life, emergency department visits, and hospitalizations.

Based on the time of presentation, acute pericarditis is a symptomatic event lasting less than four to six weeks. The diagnosis is based on meeting two of four criteria: chest pain, pericardial rub; electrocardiogram changes; and new or worsening pericardial swelling. Elevation of inflammatory markers such as CRP and evidence of pericardial inflammation by an imaging technique (computed tomography scan or cardiac magnetic resonance) may help diagnose and monitor disease activity.

Although generally self-limited and not life-threatening, acute pericarditis is diagnosed in 0.2% of all in-hospital cardiovascular admissions. It is responsible for 5% of emergency room admissions for chest pain in North America and Western Europe.

Recurrent pericarditis is the reappearance of symptoms after a symptom-free period of at least 4–6 weeks following an episode of acute pericarditis. These recurrences appear in 15% to 30% of acute cases, usually within 18 months. Up to 50% of patients with a recurrent episode of pericarditis experience more recurrences.

Cardiol believes there is a significant opportunity to develop a novel, well-tolerated, and safe therapy for treating recurrent pericarditis to prevent multiple recurrences in the first place.

Moreover, both acute myocarditis and recurrent pericarditis have a prevalence under 200,000 people in the United States. This means CardiolRx™ is eligible for orphan drug status in two indications, potentially adding significantly more value to the company.

Air pollution is a rapidly growing primary health concern around the world. Medical solutions are the next best option if pollution can't be eradicated.

GlaxoSmithKline (NYSE: GSK) is a leader in treating respiratory disease, producing MDIs that use a propellant to deliver the medicine and Dry Powder Inhalers (DPIs) which are propellant free. GSK’s latest generation of inhaler products that use the Ellipta device were developed and launched as DPIs and have an acknowledged lower carbon footprint than MDIs.

AstraZeneca (NASDAQ: AZN) is working with governments and policymakers worldwide to address systemic challenges and make COPD a public health priority. It aims to cut the COPD exacerbation rate in half by 2030 and thus reduce the associated cardiovascular mortality risk.

Regeneron Pharmaceuticals Inc (NASDAQ: REGN) enjoyed European Commission (EC) approval of its Dupixent (Dupilumab) drug for the treatment of severe asthma in children aged 6 to 11 years in April 2022.

Share:

In this article:

Topics:
Healthcare Services
Healthcare Technology
Industries:
Healthcare
Companies:
Cardiol Therapeutics

IMPORTANT NOTICE AND DISCLAIMER

PAID ADVERTISEMENT

This communication is a paid advertisement. ValueTheMarkets is a trading name of Digitonic Ltd, and its owners, directors, officers, employees, affiliates, agents and assigns (collectively the “Publisher”) is often paid by one or more of the profiled companies or a third party to disseminate these types of communications. In this case, the Publisher has been compensated by Cardiol Therapeutics to conduct investor awareness advertising and marketing and has paid the Publisher the equivalent of One Hundred and Eighty Thousand Dollars to produce and disseminate this and other similar articles and certain related banner advertisements. This compensation should be viewed as a major conflict with the Publisher’s ability to provide unbiased information or opinion.

CHANGES IN SHARE TRADING AND PRICE

Readers should beware that third parties, profiled companies, and/or their affiliates may liquidate shares of the profiled companies at any time, including at or near the time you receive this communication, which has the potential to adversely affect share prices. Frequently companies profiled in our articles experience a large increase in share trading volume and share price during the course of investor awareness marketing, which often ends as soon as the investor awareness marketing ceases. The investor awareness marketing may be as brief as one day, after which a large decrease in share trading volume and share price may likely occur.

NO OFFER TO SELL OR BUY SECURITIES

This communication is not, and should not be construed to be, an offer to sell or a solicitation of an offer to buy any security.

INFORMATION

Neither this communication nor the Publisher purport to provide a complete analysis of any company or its financial position.

This communication is based on information generally available to the public and on an interview conducted with the company’s CEO, and does not contain any material, non-public information. The information on which it is based is believed to be reliable. Nevertheless, the Publisher does not guarantee the accuracy or completeness of the information. Further, the information in this communication is not updated after publication and may become inaccurate or outdated. No reliance should be placed on the price or statistics information and no responsibility or liability is accepted for any error or inaccuracy. Any statements made should not be taken as an endorsement of analyst views.

NO FINANCIAL ADVICE

The Publisher is not, and does not purport to be, a broker-dealer or registered investment adviser or a financial adviser. The Publisher has no access to non-public information about publicly traded companies. The information provided is general and impersonal, and is not tailored to any particular individual’s financial situation or investment objective(s) and this communication is not, and should not be construed to be, personalized investment advice directed to or appropriate for any particular investor or a personal recommendation to deal or invest in any particular company or product. Any investment should be made only after consulting a professional investment advisor and only after reviewing the financial statements and other pertinent corporate information about the company. Further, readers are advised to read and carefully consider the Risk Factors identified and discussed in the advertised company’s SEC, SEDAR and/or other government filings. Investing in securities, particularly microcap securities, is speculative and carries a high degree of risk. Past performance does not guarantee future results.

FORWARD LOOKING STATEMENTS

This communication contains forward-looking statements, including statements regarding expected continual growth of the featured companies and/or industry. Statements in this communication that look forward in time, which include everything other than historical information, are based on assumptions and estimates by our content providers and involve risks and uncertainties that may affect the profiled company’s actual results of operations. These statements involve known and unknown risks, uncertainties and other important factors that could cause the actual results and performance to differ materially from any future results or performance expressed or implied in the forward-looking statements. These risks, uncertainties and other factors include, among others: the success of the profiled company’s operations; the size and growth of the market for the company’s products and services; the company’s ability to fund its capital requirements in the near term and long term; pricing pressures; changes in business strategy, practices or customer relationships; general worldwide economic and business conditions; currency exchange and interest rate fluctuations; government, statutory, regulatory or administrative initiatives affecting the company’s business.

INDEMNIFICATION/RELEASE OF LIABILITY

By reading this communication, you acknowledge that you have read and understand this disclaimer in full, and agree and accept that the Publisher provides no warranty in respect of the communication or the profiled company and accepts no liability whatsoever. You acknowledge and accept this disclaimer and that, to the greatest extent permitted under applicable law, you release and hold harmless the Publisher from any and all liability, damages, injury and adverse consequences arising from your use of this communication. You further agree that you are solely responsible for any financial outcome related to or arising from your investment decisions.

TERMS OF USE AND DISCLAIMER

By reading this communication you agree that you have reviewed and fully agree to the Terms of Use found here https://www.valuethemarkets.com/terms-conditions/ and acknowledge that you have reviewed the Disclaimer found here https://www.valuethemarkets.com/disclaimer/. If you do not agree to the Terms of Use, please contact valuethemarkets.com to discontinue receiving future communications.

INTELLECTUAL PROPERTY

All trademarks used in this communication are the property of their respective trademark holders. Other than valuethemarkets.com, the Publisher is not affiliated, connected, or associated with, and the communication is not sponsored, approved, or originated by, the trademark holders unless otherwise stated. No claim is made by the Publisher to any rights in any third-party trademarks other than valuethemarkets.com.

AUTHORS: VALUETHEMARKETS

valuethemarkets.com and Digitonic Ltd and our affiliates are not responsible for the content or accuracy of this article. The information included in this article is based solely on information provided by the company or companies mentioned above. This article does not provide any financial advice and is not a recommendation to deal in any securities or product. News and research are not recommendations to deal, and investments may fall in value so that you could lose some or all of your investment. Past performance is not an indicator of future performance.

ValueTheMarkets do not hold any position in the stock(s) and/or financial instrument(s) mentioned in the above piece. ValueTheMarkets have been paid to produce this piece by the company or companies mentioned above. Digitonic Ltd, the owner of valuethemarkets.com, has been paid for the production of this piece by the company or companies mentioned above.


Sign up for VTM Updates

Form submitted successfully!

VTM Exclusive Reports

Crypto Corner

Learn your NFTs from your BTCs